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Año 2011, Volumen 61 - Número 4
Año 2011, Volumen 61
Número 4


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HOME > EDICIONES > Año 2000, Volumen 50 - Número 3

Trabajos de Investigación
Modificaciones de los lípidos séricos de ratas suplementadas con cobre por vía oral

Oscar M. Alarcón-Corredor, Elizabeth Carnevalí de Tatá, José Reinosa-Füller, Yaritza Contreras, María Ramírez de Fernández y Claudia Yánez-Domínguez
Facultad de Medicina y Facultad de Farmacia, Universidad de Los Andes. Mérida, Venezuela.

SUMMARY
Changes in serum lipids in rats treated with copper

Disturbances in lipid metabolism during copper deficiency in rats are well recognized. Copper deficiency is associated with the spontaneous retention of hepatic iron. Previous studies have reported that hypercholesterolemia and hypertriglyceridemia are associated with elevated hepatic iron concentrations in copper deficient rats. There was a direct relationship between the magnitude of blood lipids and the concentration of hepatic iron. Based on these data, it has been hypothesized that iron was responsible for the development of lipemia of copper deficiency. In this study was determined the effect of increasing doses of Cu (10, 20 and 50 ppm) in the diet, on the serum total lipids, total cholesterol, triglycerides (triacylglicerols), phospholipids, non-esterified fatty acids (NEFA) and liver iron and zinc concentrations in normal rats. The results were compared with normal rats that received a balanced diet containing 0,6 and 6 ppm of Cu, respectively. The results show that Cu-supplement diminished the cholesterol and triglyceride serum levels, increased the level of phospholipids, NEFA and concomitantly decreased the hepatic concentrations of Fe and Zn. There was a statistically significant (p<0.05) simple correlation between triglycerides and liver Fe (r= 0,917; R2=64.03%), cholesterol and liver Zn (r=0.872; R2= 76,07%), cholesterol and liver Fe (r=0,995; R2= 99,1 0%), liver Fe and liver Cu (r= -0,612), liver Fe and liver Zn (r= 0,837),liver Cu and liver Zn (r= -0,612), and serum triglycerides and liver Zn (r=0,967). The mechanism (s) by which Fe and Zn determine these changes is not known; none of the enzymes that act in cholesterol and triglyceride metabolism and biosynthesis require Fe and/or Zn. The increase of NEF A is due to changes in the process oflipolysis and re-esterification ofthe fatty acids in blood. However, additional studies are needed for the precise mechanisms of this interrelationships to be clarified.

Key words: Correr, lipid metabolism, serum cholesterol, triglycerides, phospholipids, non-esterified fatty acids, liver iron, liver zinc.



Recibido: 16/06/1999
Aceptado: 26/07/2000



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