HOME > EDICIONES > Año 2004, Volumen 54 - Número 3
Trabajos de Investigación
Efecto de un desayuno con alto contenido en grasa o en carbohidratos sobre el perfil de lípidos posprandial en individuos sanos con y sin antecedente familiar de diabetes mellitus tipo 2
Manuel González-Ortiz, Blanca R. Balcázar-Muñoz, José M. Mora-Martínez, Esperanza Martínez-Abundis.
Unidad de Investigación Médica en Epidemiología Clínica, Hospital de Especialidades, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social. Guadalajara, México.
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SUMMARY
Effect of a high fat or high carbohydrate breakfast on postprandial lipid profile in healthy subjects with or without family history of type 2 diabetes mellitus
The objective of this study was to evaluate the effect of a high fat or high carbohydrate breakfast on postprandial lipid profile in healthy subjects with or without family history of type 2 diabetes mellitus. A single blind, controlled clinical trial with parallel groups was performed in 20 healthy subjects; 10 subjects with family history of type 2 diabetes mellitus and 10 individuals without that background. Each group was randomized to receive a high fat or high carbohidrate breakfast. A metabolic profile that included fasting and postprandial lipids, as well as, the assessment of insulin sensitivity were performed. Lower high-lipoprotein cholesterol (p < 0,02) and apolipoprotein A1 (p < 0,03) concentrations were found in subjects with family history of type 2 diabetes mellitus than those without that background. In this same above mentioned group with the high carbohydrate breakfast, there were significant increments in apoliprotein B at minute 300 (p < 0,03) and in triglycerides at minute 360 (p < 0,03). In the group without family history of diabetes that received the high fat breakfast, there were increments in triglycerides (p < 0,03) and very-low density lipoprotein concentrations at minute 180 (p < 0,03). In conclusion, healthy subjects with family history of type 2 diabetes showed some atherogenic characteristics in their metabolic profile, and the high carbohydrate breakfast produced in them increments in apolipoprotein B and in triglycerides, meanwhile that, in those subjects without such background the high fast breakfast produced unfavorable effects on their lipid concentrations.
Key words: Family history of type 2 diabetes mellitus, postprandial lipid profile, Apolipoproteins, Triglycerides.
Recibido: 06/06/2003
Aceptado: 22/06/2004
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PRIVACIDAD | ACCESIBILIDAD
ALAN-VE ISSN 0004-0622 - Depósito Legal: pp 199602DF83
Sociedad Latinoamericana de Nutrición
Producción editorial en Venezuela: Capítulo Venezolano - RIF: J-30843129-0
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