HOME > EDICIONES > Año 2004, Volumen 54 - Número 3
Artículos Generales
Efeitos terapêuticos dos fitosteróis e fitostanóis na colesterolemia
Silvia L. C. Martins1, Heliênia F. Silva1, Maria Rita Carvalho Garbi Novaes2 , Marina Kiyomi Ito1
Departamento de Nutrição. Faculdade de Ciências da Saúde. Universidade de Brasília1. Faculdade de Medicina. Fundação de Ensino e Pesquisa em Ciências da Saúde. Brasília-DF, Brasil2
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SUMMARY
Therapeutic effects of phytosterols and phytostanols in cholesterolemia
Plant sterol and stanol esters are called "functional" compounds due to their hypocholesterolemic properties. The objective of this review is to update recent findings concerning the effect of phytosterols in the blood cholesterol, emphasizing the results from experimental and human studies. The hypocholesterolemic effect is observed with the intake of 2.5g/day of phytosterols or phytostanols. Daily intake, usually of stanols, for 4 weeks has shown to to be effective in lowering blood total- as well as LDL-cholesterol by about 10%. The mechanism of action in lowering blood cholesterol comes from their structural similarity to cholesterol, hence they act by competing with cholesterol at the luminal absorption site. The adverse effects of a high intake of phytosterols and phytostanols are the lower absorption of some liposoluble vitamins and antioxidants.
Key words: Pphytosterols, phytostanols, blood cholesterol.
Recibido: 20/10/2003
Aceptado: 11/06/2004
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PRIVACIDAD | ACCESIBILIDAD
ALAN-VE ISSN 0004-0622 - Depósito Legal: pp 199602DF83
Sociedad Latinoamericana de Nutrición
Producción editorial en Venezuela: Capítulo Venezolano - RIF: J-30843129-0
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