HOME > EDICIONES > Año 2007, Volumen 57 - Número 2
Trabajos de Investigación
Estudio comparativo entre dos fuentes alimentarias aportadoras de ácidos grasos poliinsaturados n-3 y su efecto sobre el timo y el perfil lipídico de ratas
Inés Fernandez, Anabel N. Pallaro y Nora H. Slobodianik
Laboratorio de Nutrición Experimental. Cátedra de Nutrición. Facultad de Farmacia y Bioquímica.
Universidad de Buenos Aires. Argentina
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SUMMARY
Comparative study between two different sources of n-3 poliunsaturated fatty acids and it effect on thymus and lipid profile in rats
In the present paper we analyzed the effect caused by different recovery diets enriched with n-3 polyunsaturated fatty acids (PUFA n-3) on thymus and serum lipid pattern. Severe depleted weanling Wistar rats (D) were divided in three groups that received during 10 days a 20% casein diet supplemented with EPA+DHA (group Cas), a 20% protein milk diet prepared using a commercial reduced-fat product enriched with linolenic and linoleic acids (group L) and a 20% casein diet as control group C. Cas and L gave each other 24 mg/day of PUFA n-3 being the ratio n-6/n-3 8.1/1 and 7.6/1, respectively. Thymus was removed and weighted and cell number were determined; blood was recollected and Total cholesterol, triacylglycerol, HDL and LDL-cholesterol fractions and myristic, palmitic, stearic, oleic, linoleic, linolenic, araquidonic, EPA and DHA fatty acid concentrations were measured in serum. Statistical analysis was performed using Anova test. Cell number were higher (p<0.01) in Cas (44.48±8.20) and in L (56.45±14.72) when compared to group D (1.80±0.70) and group C (23.70±4.04). L presented lower values of cholesterol, HDL and LDL-cholesterol (p<0.01) and higher values of triacylglycerol (p<0.05) when compared to Cas, being EPA (p<0.05) and DHA (p<0.01) higher in Cas. Being PUFA n-3 contribution the same in Cas and L, both diets were able to reverse the thymic athropy presenting a different hipolipemic behavior due to the different sources of PUFA n-3 used in the diets.
Key words: PUFA n-3, thymus, nutritional recovery, lipid profile, EPA, DHA, linoleic acid.
Recibido: 29/03/2007
Aceptado: 27/06/2007
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PRIVACIDAD | ACCESIBILIDAD
ALAN-VE ISSN 0004-0622 - Depósito Legal: pp 199602DF83
Sociedad Latinoamericana de Nutrición
Producción editorial en Venezuela: Capítulo Venezolano - RIF: J-30843129-0
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