CO097. N-3 PUFA HABITUAL INTAKE IS ASSOCIATED WITH ADIPOKINES IN MEXICAN TYPE 2 DIABETES POPULATION

Background: Changes in lifestyle have led to an increase in the global incidence of type 2 diabetes mellitus (T2DM). In Mexico there are 6.4 million type two diabetic patients. There is evidence that T2DM is associated with low-grade chronic inflammation and the beneficial effect of polyunsaturated fatty acids (PUFA) n-3 in patients with chronic inflammatory diseases. Objective: To investigate the relationship between habitual fatty acid intake and circulating proinflammatory adipokines in patients with T2DM in the population of the State of Mexico. Methods: We conducted a cross-sectional study in a sample of 80 diabetic adults (40 with normal weight (NW) and 40 overweight (OW)) to whom we measured BMI, waist circumference, body fat percentage and blood pressure as well as PUFA dietary intake, biochemical parameters, adiponectin and resistin). Results: Low n-3 intake was found in both groups (0.66 ± 0.4 g/day in NW vs 0.69 ± 0.5 g/day in OW,); n-3:n-6 ratio was adequate in both groups (5.8 in NW vs 6.8 in OW). Comparison between groups showed significantly higher concentrations of adiponectin in the OW group as well as significant correlations between total n-3 fatty acid intake and serum adiponectin (r= -.192, p=0.003), and resistin (r=-.210, p=0.002). Conclusions: Diabetic patients with overweight had higher adipokine concentrations than subjects with normal weight, were inversely related to n-3 intake.