PO 272. CORRELATION BETWEEN ANTI-GHRELIN AND ANTI-LEPTIN AUTOANTIBODIES WITH BODY COMPOSITION AND APPETITIVE TRAITS IN YOUNG ADULTS
- Universidad de Guadalajara, Zapotlán el Grande, México
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Abstract
PO 272. CORRELATION BETWEEN ANTI-GHRELIN AND ANTI-LEPTIN AUTOANTIBODIES WITH BODY COMPOSITION AND APPETITIVE TRAITS IN YOUNG ADULTS
Background and objective. Ghrelin and leptin are key hormones regulating appetite and metabolism, both circulate in bloodstream bound to serum proteins including low-affinity autoantibodies (autoAbs) directed against these hormones, specifically immunoglobulins of the G isotype (IgG). Eating behavior can be regulated by ghrelin and leptin and their alteration is associated with changes in body composition. The goal of this study was to analyze anti-ghrelin and anti-leptin autoAbs in sera from young adults and evaluate their correlation with body composition and appetitive traits.
Methods. Anti-ghrelin and anti-leptin IgG were measured in serum with a validated in-house ELISA test, which allows quantification of free, total fractions, and immune-complexes percentage. Body composition was measured by bioelectrical impedance. Appetitive traits were assessed via the Adult Eating Behaviour Questionnaire, which comprises 4 ‘food approach’ subscales. Food Responsiveness (FR), Enjoyment of Food (EF) and Emotional overeating (EOE) and 4 ‘food avoidance’ subscales. Satiety Responsiveness (SR), Emotional under-eating (EUE), Food Fussiness (FF) and Slowness in Eating (SE).
Results. One hundred and eighty adults were included in the study (mean age 20±2 years), 69% were females. 46% of the subjects had an ideal body fat percentage (BF%) and 54% had above-average BF%. Correlation analysis were made according to sex and BF%. Both anti-ghrelin and anti-leptin immune-complexes showed a positive correlation between waist-hip ratio (r=0.21,p=0.0044 and r=0.17,p=0.0180, respectively). In women, free and total anti-ghrelin autoAbs were higher in those who scored lower in EF and FF appetitive traits (p=0.0293,p=0.0328, respectively); immune-complexes were higher in those who scored higher in EF (p=0.0258). In men, free anti-leptin autoAbs were higher in subjects who scored higher in EUE (p=0.0294) whereas immune-complexes were higher in those who scored lower in EUE (p=0.0282).
Conclusion. These results support the role of IgG autoantibodies directed against ghrelin and leptin as carriers/protective of the hormone and evidence of their potential contribution in regulating eating behavior.
