Comunicaciones Orales


Thabata Patrícia Fátima Sousa Novais2, Thabata Koester Weber1, Renata Maria Galvão Cintra1, Emilia Alonso Balthazar3, Irineu Rasera júnior4, Maria Rita Marques de Oliveira1,2.

1 Institute of Biosciences of the Paulista State University (UNESP), Botucatu/SP, Brazil; 2 Graduate Program in Food and Nutrition – Nutrition Sciences, Paulista State University, School of Pharmaceutical Sciences (UNESP-FcFar), Araraquara/SP, Brazil; 3 Science Health College - Federal University of Grande Dourados, Dourados/MS, Brazil; 4 Gastroenterology and Obesity SurgeryCenter – Bariatric Clinic, “Hospital Fornecedores de Cana”, Piracicaba/SP, Brazil.

Background: Obesity is a serious public health problem resulting from the interaction of genetic, environmental, and metabolic factors. Extreme cases have been controlled with bariatric surgery. Food intake after surgery varies and little is known about the influence of genetics. Objective: To assess whether any of the study twelve polymorphisms affect energy and macronutrient intakes or body weight one year after Roux-en-Y gastric bypass. Methods: This is a prospective study of adult women submitted to roux-en- Y gastric bypass. Anthropometric measurements and three food records were collected before and one year after surgery. The study single-nucleotide polymorphisms were: GHRL rs26802; GHSR rs572169; LEP rs7799039; LEPR rs1137101; 5-HT2C rs3813929; UCP2 rs659366; UCP2 rs660339; UCP3 rs1800849; SH2B1 rs7498665; TAS rs35874116; TAS rs9701796; and FTO rs9939609. Results: The women were divided into percentage of excess weight loss (%EWL) quartiles. Women in the first and second quartiles had higher BMI. Women in the fourth quartile lost more weight than those in the first quartile with higher BMI. All %EWL quartiles had similar energy and macronutrient intakes before and one year after surgery. Additionally, energy and macronutrient intakes before and after surgery were similar in all quartiles. None of the study polymorphisms were associated with the reported energy intake one year after surgery. Conclusion: The study genetic polymorphisms did not influence the food intake of women one year after Roux-en-Y gastric bypass.