Comunicaciones Orales


Regina Célia Vilanova Campelo1, Marcus Vinícius Nascimento-Ferreira2, Tara Rendo Urteaga2, Augusto César Ferreira de Moraes2, Heraclito Barbosa de Carvalho2, Luis Alberto Moreno3, Germano da Paz Oliveira4, Maurício Batista Paes Landim4, Francisco Leonardo Torres-Leal1.

1 Department of Biophysics and Physiology, Health Science Center, Federal University of Piauí, Brazil. 2 Youth/Child and Cardiovascular Risk and Environmental (YCARE) Research Group, Research Group, School University of São Paulo, São Paulo, Brazil; 3 Growth, Exercise, Nutrition and Development (GENUD) Research Group, School of Health Science (EUCS), University of Zaragoza, Zaragoza, Spain. 4 Hospital of the Federal University of Piauí, Piauí, Brazil.

Background: The lipid accumulation product (LAP) is a relatively simple and new marker for measuring cardiovascular disease (CVD). We assessed the association between LAP index and high density lipoprotein-cholesterol (HDLc), low density lipoproteincholesterol (LDLc), very low density lipoprotein-cholesterol (VLDL), total cholesterol (TC) and TC/HDL ratio (the atherogenic index) in asymptomatic adults from Brazil. Methods: We conducted a cross-sectional study with asymptomatic patients aged 20-60 years (n=201; 37.8% men) in Teresina (Piauí, Brazil), selected by probability sampling simple random. In the study were included patients without previous diagnosis of CVD and that didn’t make use of continuous medication. The HDLc, LDLc, VLDL, TC and TC/HDL ratio (outcomes) were collected by 12-hour fasting blood samples and evaluated by Clinical Analysis Laboratory of the University Hospital of Federal University of Piauí. The LAP index was calculated as [waist circumference (cm)–65]×[triglycerides (mmol/L)] for men, and [waist circumference (cm)–58]×[triglycerides (mmol/L)] for women (exposure factor). Associations were examined by multilevel linear regression, with confidence interval of 95% (CI95%). The analyses were adjusted for potential confounders: age, body mass index (kg/m2) and physical activity (≥60 minutes/day), and stratified by sex. Results: Among male adults LAP index (mean±SD) was: 73.2±46.3, and for female was: 61.7±51.6. In men, we found significant associations between LAP-HDLc (β:-0.07; CI95%:-0.13 to -0.01), LAP-VLDL (β:2.85; CI95%:1.64 to 4.05), LAP-TC (β:0.34; CI95%:0.06 to 0.61) and LAP-TC/HDL ratio (β:0.02; CI95%:0.01 to 0.03). On the other hand, for women we found significant associations between LAP-HDLc (β:-0.07; CI95%:-0.12 to -0.02), LAPVLDL (β:1.04; CI95%:0.48 to 1.60), LAP-TC (β:0.31; CI95%:0.16 to 0.45) and LAP-TC/HDL ratio (β:0.01; CI95%:0.01 to 0.02). We not found significant association between LAP and LDLc. Conclusions: There is a strong association between LAP and atherogenic markers in our population. The LAP may be a simple tool to predict cardiovascular risk in asymptomatic Brazilian adults.